{"product_id":"metastasis-of-prostate-cancer-by-richard-j-ablin","title":"Metastasis of Prostate Cancer by Richard J Ablin | ISBN-13 9789401781527","description":"\u003cp\u003eExplore \u003cstrong\u003eMetastasis of Prostate Cancer by Richard J Ablin\u003c\/strong\u003e by Richard J Ablin, a valuable resource for readers seeking subject knowledge, key concepts, and a deeper understanding of the topic.\u003c\/p\u003e\u003cp\u003eMetastasis of Prostate Cancer by Richard J Ablin Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible, then a knowledge of the phenotype of advanced metastatic tumors should allow us to target these lesions for destruction by conventional (drug based) or more innovative means such as gene and\/or immunotherapy (1). The process of metastasis has been reviewed many times (e. g., 2) and has been subdivided for ease of analysis into a number of discrete stages (see Figure 1). It has been suggested that at least 10 separate genetic 2. ECM degradation: migration MMP; Integrin; TIMP 3. Intravasation MMP TIMP 1. Cellular independence 4. Transport Adhesion loss and evasion (E Cadherin ) of host immune system MHCClass1 ICAM-1 to block T cell receptor 5. Arrest of movement: endothelial adhesion CD44 or switch 6. Extravasation to colonise new site 7. Proliferation at Laminin R distant site to form Integrin switch METASTASIS Figure 1. Stages in prostate cancer metastasis. Basic processes in tumor metastases are indicated in the boxes with some key changes in gene expression indicated at each stage by the solid arrows.\u003c\/p\u003e\u003ch3\u003eBook details\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eISBN-13:\u003c\/strong\u003e 9789401781527\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAuthor:\u003c\/strong\u003e Richard J Ablin\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublisher:\u003c\/strong\u003e Springer\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePublication year:\u003c\/strong\u003e 2014\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePages:\u003c\/strong\u003e 407\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eElectronic edition. Please review the product details before purchase to confirm this format meets your needs.\u003c\/p\u003e","brand":"Springer","offers":[{"title":"Default Title","offer_id":66301384950109,"sku":null,"price":39.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0873\/8911\/0621\/files\/9789401781527.jpg?v=1792754412","url":"https:\/\/highscorecomics.com\/products\/metastasis-of-prostate-cancer-by-richard-j-ablin","provider":"High Score Comics","version":"1.0","type":"link"}